1. A generalized inflammatory and senescence-associated response induced by chemotherapy2. Heterogeneity within progenitor AML cells: OxPhoshigh vs miR-126highOxPhoslow3. miR-126highOxPhoslow LSCs are more quiescent with stemness, associated with refractory and relapse in NPM1 mutant AML. Here, NPM1 is linked to acute myeloid leukemia.