Refractory/relapsed AML shows relatively higher abundance of clusters enriched with expression of the inhibitory receptor KLRG1, a marker of antigen-experienced and senescent cells (99, 100), while newly diagnosed AML displays relative higher percentage of clusters expressing cell-migratory receptor CXCR4 and AP-1 transcription factor FOSB (94). This evidence concerns the gene FOSB and acute myeloid leukemia.