WNT1-inducible-signaling pathway protein 2 (WISP2), known to inhibit MSCs ability to differentiate, was observed to be upregulated in all LepR+ BMSCs subsets as well as OLC progenitors, suggesting a compromised differentiation of LepR+ BMSCs and OLCs in AML (80). Here, LEPR is linked to acute myeloid leukemia.