Specifically, reduced levels of GFD15 have been reported in placental and serum samples of women with unexplained recurrent pregnancy loss, compared to controls, and in mice, reduced placental and serum GDF15 have been associated with increased embryo resorption (the murine equivalent of miscarriage), which could be reversed by GDF15 administration [35, 36]. The gene discussed is GDF15; the disease is spontaneous abortion.