CD8A and Alzheimer disease: Figure 8A demonstrates that AD samples have a higher proportion of resting natural killer (NK) cells, macrophages, and mast cells compared to healthy samples. Conversely, CD8 T cells were found to be expressed at lower levels in AD samples. Furthermore, we conducted a Pearson correlation analysis and discovered that regulatory T cells were positively correlated with the expression of MUC1, KLHL24, and DDIT4 (Figure 8B). Figure 8B illustrates that the expression of RB1 is negatively correlated with eosinophils and CD8 T cells.