We observed a decreased expression of the HLF gene in the tumor tissues of many different human malignancies, such as ACC, BLCA, BRCA, CESC, COAD, GBM, HNSC, KIRC, KICH, LUAD, LUSC, PRAD, READ, SKCM, STAD, THCA, UCEC, and UCS. This evidence concerns the gene HLF and glioblastoma.