Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized neuropathologically by insoluble extracellular plaques of amyloid-β (Aβ) and intracellular neurofibrillary tangles of hyperphosphorylated tau (p-tau) resulting in cognitive decline, dementia, and death [1]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.