Quercetin induces transcriptional expression of ERS-related factors PERK, eIF2α, ATF4, and CHOP, while transcriptional expression of the apoptosis-related factors Bax, caspase-3, and cyt-c is also significantly upregulated, and transcriptional expression of the anti-apoptotic protein Bcl-2 is markedly inhibited; this cumulatively suggests that quercetin induces cervical cancer cell apoptosis via ERS (133). The gene discussed is ATF4; the disease is cervical carcinoma.