Mitochondrial carrier 1 (MTCH1) is a central mediator of mitochondrial-mediated ferroptosis (MMF) in cervical cancer, and its deletion disrupts mitochondrial OXPHOS and initiates FoxO1-GPX4 axis-mediated retrograde signaling, which increases ROS and ultimately triggers ferroptosis (101). The gene discussed is MTCH1; the disease is cervical cancer.