Since peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC1α), a major mitochondrial biosynthesis regulator, is a key molecule in integrating and coordinating the transcriptional machinery of nuclear and mitochondrial DNA, it may be a target for improving chemotherapy efficacy and mediating ovarian cancer cell participation in cisplatin-resistant OXPHOS via nuclear-mitochondrial transcriptional feedback (48). This evidence concerns the gene PPARGC1A and ovarian cancer.