Tanshinone I significantly inhibits cervical cancer SiHa cell proliferation, migration, and invasive ability in drug concentration- and time-of-action-dependent manners, interacting with BNIP3/NIX through hydrogen bonding and significantly affecting these cells’ differentially expressed gene profiles and metabolic reprogramming; it also promotes expressions of mitochondrial autophagy-related proteins BNIP3, NIX, and optineurin, which promote conversion of LC3I to LC3II and inhibit expressions of NDP52 and P62 (137). The gene discussed is CALCOCO2; the disease is cervical cancer.