PRKN and ovarian cancer: Depletion of the well-defined E3 ubiquitin ligase CRL4CUL4A/DDB1 upregulates phosphorylation of 5’ AMP-activated protein kinase (AMPK)αThr172 and MFFSer172/Ser146 to enhance mitochondrial fission, which in turn recruits DRP1 into mitochondria; its absence stimulates mitochondrial autophagy via the PINK1/parkin pathway, degrading dysfunctional and fragmented mitochondria and manipulating ovarian cancer cell chemoresistance (68).