C1QBP and neoplasm: For example, while overexpression of gC1qR suppresses the tumor inhibiting role of C1q and promotes tumor proliferation in multiple myeloma (48), gC1qR overexpression in some tumor cells such as mesothelioma is associated with better prognosis and survival when compared to breast cancer cells particularly when the tumor microenvironment is infiltrated with gC1qR expressing CD8 lymphocytes (24).