C1QBP and neoplasm: Moreover, since the expression of C1q on tumor cells also plays a critical role in tumor cell survival through interaction with and suppression of gC1qR expressing T cells, an antibody that targets the gC1qR site on gC1q could also be another option to disrupt the C1q-mediated T cell suppression Therefore, we believe that the development of anti-gC1qR therapy alone or in combination with anti-C1q could enhance presently available therapies to treat not only breast cancer, but other types of cancer as well.