For example, gC1qR blockade with monoclonal antibodies (mAbs)– i.e. mAb 60.11, which recognizes the C1q site on gC1qR and mAb 74.5.2, which recognizes the HK site on gC1qR–may diminish the host response to local infection such as decreased migration of neutrophils and macrophages into sites of infections as a result of decreased local production of C3a (chemoattractant) (mAb 60.11) and C5a (mAb 60.11), as well as bradykinin (mAb 74.5.2) (vascular permeability). Here, C3 is linked to infection.