Dysregulated innate viral defense mechanisms induce hyperactive JAK/STAT-signaling and Type-I-mediated gene expression reminiscent of type-I-interferonopathies, presenting with usually severe autoinflammatory diseases such as SLE-type or Aicardi-Goutières-syndrome (38, 39). Here, SOAT1 is linked to Aicardi-Goutières syndrome.