Although numerous studies have urged that an increased Nrf2 and an augmented and functional Treg population is necessary to treat allergic asthma, our study notably demonstrates that DMF treatment surges the Nrf2 expression predominately in the Treg, where Nrf2 acts as a helping hand in promoting the level of Foxp3 and the differentiation of Tregs. The gene discussed is NFE2L2; the disease is allergic asthma.