Apart from this, the authors also selectively induced genetic deficiency of GLUT5 in adipocytes by utilizing Adipoq-Cre : Slc2a5fl/fl mice and found that upon their challenge with melanoma, these mice had lower serum leptin levels, lesser tumor-infiltrating CD8+ T cells and larger tumor size post high-fructose diet (39). This evidence concerns the gene LEP and neoplasm.