Based on the existing AOSD cytokine cluster analysis, Gal-3 appears to be associated with the cytokines involved in CD4+ T cell development, activation, or function (including interferon alpha-2, basic FGF, IL-2, and IL-3) and with the cytokines involved in the cytokine release syndrome (including IL-18, CXCL10, M-CSF, and IL-1Ra) (40, 41). This evidence concerns the gene IL18 and adult-onset Still disease.