Cluster 1 showed significant correlations between Gal-3 and basic FGF (r = 0.70, p <0.0001), LIF (r = 0.66, p <0.0001), CCL27 (r = 0.65, p <0.0001), CXCL11(r = 0.65, p <0.0001), IL-1Ra (r = 0.63, p <0.0001), IL-2Ra (r = 0.63, p <0.0001), IL-3 (r = 0.62, p <0.0001), M-CSF (r = 0.58, p <0.0001), IL-18 (r = 0.58, p <0.0001), IFN-a2 (r = 0.53, p <0.0001), MIP-3b/CCL19 (r = 0.53, p = 0.0002), and IP-10/CXCL10 (r = 0.50, p = 0.0006) in patients with AOSD (Table 2A). This evidence concerns the gene IL18 and adult-onset Still disease.