IGHE and asthma: The type-2 (T2)-inflammatory endotype, associated with increased blood eosinophil count (BEC) and/or fractional exhaled nitric oxide (FeNO) concentrations or total immunoglobulin E (IgE) and specific IgE, is estimated to account for up to 80% of adults with severe asthma using an algorithm informed by these biomarkers (and clinical characteristics) and developed by expert consensus (2–4).