The tumor and normal tissue uptake of [64Cu]Cu-NOTA-trastuzumab Fab-PEG24-EGF bsRICs or monospecific [64Cu]Cu-NOTA-trastuzumab Fab or [64Cu]Cu-NOTA-EGF were determined at 48 h p.i. in mice with SK-OV-3 tumors or tumors formed from a mixture of SK-OV-3 cells (30%) and MDA-MB-468 cells (70%). The gene discussed is EGF; the disease is neoplasm.