NOS2 and infection: Ingenuity pathway analysis (IPA) of the DEGs between WT and RELMα KO lung cells indicated changes in JAK, cytokine, Tnfr2, antigen presentation, iNOS, toll-like receptors, and Th1 signaling pathways (Figure 5C; Table 2). When comparing gene expression in lung cells infected RELMαΔCC10 and RELMαF/F mice at 30 days post infection, PCA analysis did not reveal distinct clusters, indicating that CC10-specific deletion of RELMα was insufficient to alter overall lung cell gene expression (Figure 5D).