Finally, GWAS2019 identified 26 AD susceptibility loci, including 7 novel loci (IQCK, ACE, ADAM10, ADAMTS1, WWOX, ECHDC3 and OARD1) and 19 previously known loci (18 loci were identified by IGAP 2013 excluding TREM2) [8]. The gene discussed is OARD1; the disease is Alzheimer disease.