They further performed a meta-analysis combining the results from the IGAP 2013 AD GWAS and GWAX2017, and identified 25 genome-wide significant genetic variants corresponding to 22 AD susceptibility loci, including four novel AD susceptibility loci (HBEGF, ECHDC3, SPPL2A and SCIMP) [9]. This evidence concerns the gene ECHDC3 and Alzheimer disease.