Therefore, 50 (61%) loci were replicated in at least 2 of these 9 studies, and only 14 (17%) loci were replicated across all these 9 AD GWAS and GWAS+GWAX datasets, including PICALM, EPHA1, CR1, CASS4, SORL1, CD2AP, ZCWPW1, ABCA7, ECHDC3, MS4A6A, SLC24A4, CLU, INPP5D and BIN1, as provided in Table 2. This evidence concerns the gene CD2AP and Alzheimer disease.