They further meta-analyzed the AD GWAX and AD GWAS from IGAP 2013 (n = 74 046) and found 26 genome-wide significant genetic variants corresponding to 26 AD susceptibility loci including 19 known loci and 7 novel loci (IL-34, SPPL2A, BCKDK/KAT8, ADAM10, TREML2, PLCG2, ACE) (GWAS+GWAX2018) [10]. This evidence concerns the gene SPPL2A and Alzheimer disease.