Therefore, 50 (61%) loci were replicated in at least 2 of these 9 studies, and only 14 (17%) loci were replicated across all these 9 AD GWAS and GWAS+GWAX datasets, including PICALM, EPHA1, CR1, CASS4, SORL1, CD2AP, ZCWPW1, ABCA7, ECHDC3, MS4A6A, SLC24A4, CLU, INPP5D and BIN1, as provided in Table 2. The gene discussed is BIN1; the disease is Alzheimer disease.