RUNX1 and acute myeloid leukemia: However, in acute myeloid leukemia (AML)‐ETO‐positive leukemia, in which MEIS2 is up‐regulated, MEIS2 plays an oncogenic role through impairing repressive DNA binding of AML1‐ETO, resulting in upregulation of proto‐oncogenes such as YES1 kinase in AML cells.19