We also analyzed the expression of MEIS2 in different stages of human BC samples, and found that MEIS2 was strongly expressed in BC cells of ductal carcinoma in situ (DCIS) (TNMs tage Tis), while the expression level of MEIS2 was decreased in stage I tumors and further decreased in stage II and III tumors (Figure 2A). The gene discussed is MEIS2; the disease is ductal breast carcinoma in situ.