Furthermore, we observed a strong CD4+ Th1 enrichment, uniquely in the PI3K/mTORi+PD‐1i‐treated tumours, which suggest the presence of this supportive CD4+ Th1 niche is crucial in maintaining the proliferative and cytotoxic functions of CD8+ Teff cells (Figure 3K).41 This evidence concerns the gene PIK3CA and neoplasm.