PIK3CA and neoplasm: To validate the finding that macrophages are reeducated towards an M1‐like polarisation in tumours treated with PI3K/mTORi and PI3K/mTORi+PD‐1i, we evaluated the expression of M1 (CD86) and M2 (CD163, CD206) markers on FFPE tissue sections from humanized EMC041 PDX tumours collected at sacrifice, using MILAN‐analysis (Figure 5H).