These data suggest that tumour cells in PI3K/mTORi‐ and most prominently PI3K/mTORi+PD‐1i‐treated tumours upregulate antigen processing and presentation in response to IFNγ produced by the enriched tumour‐infiltrating T‐cell population, which in turn makes them more prone to T‐cell attack. This evidence concerns the gene PIK3CB and neoplasm.