However, macrophages in the PI3K/mTORi‐ and PI3K/mTORi+PD‐1i‐treated tumours expressed higher M1‐gene signatures compared to other conditions, suggesting that macrophages in tumours treated with PI3K/mTORi and PI3K/mTORi+PD‐1i adopt an M1‐like anti‐tumourigenic polarisation (Figure 5E). The gene discussed is PIK3CA; the disease is neoplasm.