PIK3CA and neoplasm: Pathway enrichment analysis based on DEGs revealed that macrophages in PI3K/mTORi‐ and PI3K/mTORi+PD‐1i‐exposed tumours upregulate pathways related to phagocytosis, T‐cell recruitment/activation and LPS‐mediated signalling (M1‐like), while downregulating pathways associated with tissue remodelling and angiogenesis (M2‐like) (Figure 5F).