In the PI3K/mTORi‐treated tumours clonal T cells were almost exclusively confined to the CD8+ Tex‐cell population, while in the PI3K/mTORi+PD‐1i‐treated tumours, clonally expanded T cells primarily belonged to the CD8+ Teff‐ and CD4+ Th1‐cell population (Figures 4A and S4C, E and F). This evidence concerns the gene PIK3CA and neoplasm.