A strong enrichment of the CD4+ Th1 (IFNGhi, TNFhi, TBX21hi, GZMBhi) subpopulation was observed exclusively in the PI3K/mTOR+PD‐1i‐treated tumours (Figure 3F) and DGE analysis revealed this population upregulates the expression of immune response promoting factors (IFNG, TNF, CSF2, TNFSF10 (TRAIL), TNFSF14 (LIGHT), CCL3) (Figure 3G). Here, TNF is linked to neoplasm.