CD4 and neoplasm: Consistently, gene set enrichment analysis in the CD4+ T‐cell population also showed upregulated expression of gene sets related to Th1 differentiation, Th1 cytokine production and Th1 immune response, suggesting improved CD4+ Th1 activity in the PI3K/mTORi+PD‐1i‐treated tumours, not found in other treatment conditions (Figure 3H).