Common signal pathways involved with advanced lung cancer, were epidermal growth factor receptor/Kirsten rat sarcoma/anaplastic lymphoma kinase (EGFR/KRAS/ALK) and C-X-C motif chemokine ligand 12/C-X-C motif chemokine receptor 4 (CXCL12/CXCR4). The gene discussed is KRAS; the disease is lung cancer.