EGFR mutations were found to be more common in multiple metastases compared to single metastasis (24/40 vs. 12/42, respectively, p = 0.004) [56], and EGFR + tumors were also associated with more frequent pleural (24.1% vs. 37.5%) and bone metastasis (31.5% vs. 53.8%) [57]. Here, EGFR is linked to bone metastasis.