They demonstrated that circLPAR1 encapsulated in exosomes could be internalized by colorectal cancer cells, and further suppressed tumour growth by directly bound with eukaryotic translation initiation factor 3 subunit h (eIF3h), suppressing the methyltransferase-like 3 (METTL3)-eIF3h interaction and decreasing the translation of oncogene bromodomain containing 4 [44]. Here, METTL3 is linked to colorectal cancer.