Having established the more pronounced expression levels of CtBP1/BARS in the two A375MM and B16F10 melanoma cell lines (Supplementary Fig. 1A), we investigated the cytotoxic effects of Comp.11 on these cells (and compared these effects with those of MTOB, HIPP and PPγ inhibitors; Fig. 5A-E, see also Supplementary Figs. 9, 10 and 11). The gene discussed is SRGN; the disease is melanoma.