Western blot analysis of cell lysates treated with Comp.11 (or with CtBP1/BARS siRNAs) showed a reduction of the well-known signaling proteins associated with melanoma development and progression: NRAS and Akt [identified as CtBP repression target, [45]], and NF-kB and STAT3 [100] (Fig. 7C and D). Here, NRAS is linked to melanoma.