Effects of Comp.11 on CtBP1 transcriptional activity results in reduced mesenchymal melanoma gene expression signatures, cancer cell proliferation, migration and invasion, and cell colony formation while effects of Comp.11 on CtBP1/BARS membrane fission activity results in mitotic Golgi-checkpoint block and exocytosis impairment. This evidence concerns the gene CTBP1 and melanoma.