Thirdly, it facilitates the binding of CYCLINL1 to Cyclin-Dependent Kinase 19 (CDK19), activating RNA Polymerase II Serine 2 (Pol II Ser2) phosphorylation and increasing Runt-Related Transcription Factor 2 (RUNX2) expression, aiding in the bone metastasis of PCa [129]. This evidence concerns the gene RUNX2 and posterior cortical atrophy.