FOXO3 and glioblastoma: On the other hand, miR-27a-3p, which is highly expressed in hypoxic GBM, can directly bind to and inhibit FTO expression, thereby inhibiting forkhead box O3 (FOXO3a) nuclear translocation, downregulating the expression of FOXO3a downstream target genes and inducing the malignant behavior of GBM [105].