Mechanistically, circ-0001187 reduces mRNA m6A modification in AML cells by enhancing the expression of E3 ubiquitin ligase RNF113A, mediating the miR-499a-5p/RNF113A/METTL3 pathway and downregulating METTL3 expression [87]. This evidence concerns the gene RNF113A and acute myeloid leukemia.