SERPINE2 and hepatocellular carcinoma: MiRNA-145 [117] and HIF-2α [118] both regulate YTHDF2 levels in HCC, however low levels of YTHDF2 fail to catalyze the decay of m6A modified interleukin 11 (IL11) and serpin family e member 2 (SERPINE2) mRNAs, which in turn leads to the initiation of inflammation and exacerbation of malignancy in HCC.