Moreover, in prostate cancer (PCa), YTHDF2 directly binds to the m6A modification sites of Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase (LHPP) and NK3 Homeobox 1 (NKX3-1), facilitating the degradation of mRNA and thereby reducing their expression levels within cells. Here, NKX3-1 is linked to Familial prostate cancer.