Finally, to have an overview of KAISO targets overlapping with REST-activated and REST-repressed genes in glioma, log2 fold change in gene expression between siKAISO and siCTRL for IDH-MUT and IDH-WT were plotted for REST-repressed (Fig. 7I) and REST-activated genes (Fig. 7J). The gene discussed is IDH2; the disease is central nervous system cancer.