We have investigated real-time gene expression of MBD1, MBD2 & MeCP2 genes as well as BRCA1, BRCA2 & p16 genes in breast cancer cells treated with different concentrations of resveratrol and discovered that MBD1, MBD2, MeCP2 and p16 gene expression was up-regulated in MCF-7 cells and BRCA1(Pearson r = -0.9581, P<0.0026), BRCA2 gene expression was down-regulated, however in MDA-MB-231 cell line except for MBD2 all genes expression up-regulated in response to increasing concentrations of resveratrol, and BRCA1 (Pearson r = 0.9257, P<0.0081) exhibits a strong positive correlation. The gene discussed is MBD1; the disease is breast cancer.