ESR1 and breast cancer: Correlation analysis demonstrated that only MBD2 has negative regulatory role on BRCA1 gene expression as well as in protein expression in ER+, PR+ & Triple negative breast cancer cells; its MBD2-BRCA1 axis indicates their significant role in the induction of apoptosis and reduction of sphere formation, colony formation, and metastasis in Breast cancer cells (Fig. 7).