In MDA-MB-231 breast cancer cells MBD1 (P<0.0001), MBD2 (P<0.0003), MeCP2 (P<0.0003), protein expression were down-regulated and significant at 40μM and BRCA2 at 50μM (P<0.0033) concentration of resveratrol. The gene discussed is MBD2; the disease is breast carcinoma.