This indicates that the MBD1 and MeCP2 gene negatively regulates the BRCA1 gene expression in ER+ and PR+ breast cancer cells and MBD2 negatively regulates the BRCA1 gene expression in ER+ & PR+ and Triple negative breast cancer cells after resveratrol treatment, however, there is no effects observed in genes expression in MCF10A breast normal cell line. This evidence concerns the gene BRCA1 and breast cancer.