Furthermore, GWAS analyses identified a novel genome-wide significant association with genetic markers in DNA variants of TMEM106B and neurofilament light chain (NfL) protein concentrations in the cerebrospinal fluid of AD patients [51], but the relationship between TMEM106B and Aβ/tau proteins in cerebrospinal fluid (CSF) of AD patients remains to be explored. Here, MAPT is linked to Alzheimer disease.