FGFR3 and neoplasm: While diverse FGFR1–FGFR3 alterations and multiple tumor types were represented, the common pattern across histologies was the emergence of mutations in the gatekeeper residues (FGFR2 V564F/I/L; FGFR3 V555L/M) or closely neighboring residues (FGFR1 V559L/M) and molecular brake residues (FGFR1 N546K; FGFR2 N549D/H/K, E565A and K641R).