In addition to patients with cholangiocarcinoma, we saw polyclonal acquired resistance in patients with FGFR2-altered gastroesophageal/gastroesophageal junction cancer and cancer of unknown primary origin, FGFR3-altered non-small cell lung cancer and FGFR1-altered pancreatic cancer. Here, FGFR1 is linked to familial pancreatic carcinoma.