We previously reported that the inactivating mutations of SMARCA4 were correlated with the epithelial-mesenchymal transition (EMT) phenotype of lung adenocarcinoma cell lines, and loss of SMARCA4 expression was frequent in poorly differentiated non-TRU-type adenocarcinomas, showing a lack of lepidic growth, low expressions of TTF-1 and wild-type EGFR [28]. Here, SMARCA4 is linked to lung adenocarcinoma.