We also compared clinicopathological factors among the six groups (Online Resource 7) and found that advanced pT factor, advanced pStage, lymph node metastasis, vessel invasion, pleural invasion, and pulmonary metastasis were most frequently observed in the HNF4α-positive grade 3 group, indicating that this group was the aggressive phenotype. This evidence concerns the gene HNF4A and metastatic malignant neoplasm in the lymph nodes.