A previous study that examined the expression of HNF4α and mucin profiles in lung mucinous adenocarcinomas [45] reported that HNF4α induced the expression of MUC3 in KRAS-mutated mucinous adenocarcinomas, which is a poor prognostic factor for mucinous adenocarcinomas of the breast and appendix [46, 47]. This evidence concerns the gene MUC5AC and mucinous adenocarcinoma.