Our results indicate that C. maritimum has potent homeostatic effects on the dysregulated metabolism of HCC cells by: i) decreasing the expression of the genes controlling lipogenesis and cholesterogenesis, ii) activating AMP-activated protein kinase (AMPK), Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3), which are well-known metabolic health markers, iii) improving insulin response related signalling. Here, SIRT1 is linked to hepatocellular carcinoma.