We also demonstrated that C. maritimum reduced the expression of HCC markers α-fetoprotein (α-FP) and α1-antitrypsin (α1-AT) and improved the sensitivity of HCC cell to anti-neoplastic drugs by determining a shift in the HCC bioenergetic profile from lactic acid fermentation to OXPHOS [19]. Here, SERPINA1 is linked to hepatocellular carcinoma.