First, we identified six cytokines and chemokines, including HGF (significant difference in cohort 1 and cohort 4, Fig. 2G and Fig. 5F) and IL-10, IP-10, SCGF-β, IL-16, and IL-18 (significant difference in cohort 3 and cohort 4, Fig. 4 and Fig. 5), that consistently showed variations in COVID-19 in different cohorts. This evidence concerns the gene IL18 and COVID-19.