Of note, when we used these genes as a signature using a mean of expression of all genes divided by subtype, we observed a high association with favourable outcome in the basal-like (RFS: HR = 0.43; CI 0.31–0.61; p = 6.9 × 10–7; OS: HR = 0.51; CI 0.31–0.83; p = 0.0053) (Fig. 5c) and HER2+ (RFS: HR = 0.6; CI 0.43–0.84; p = 0.0027; OS: HR = 0.48; CI 0.28–0.83; p = 0.0076) breast cancer subtypes (Fig. 5d). The gene discussed is ERBB2; the disease is breast cancer.