The APOE-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${{{{{\mathcal{E}}}}}}4$$\end{document}E4 allele has been associated with a range of traits, including increased risk of hypercholesterolaemia and coronary artery disease and reduced risk of obesity and type 2 diabetes37. Here, APOE is linked to Hypercholesterolemia.