In our previous study, we reported that S100A16 promotes acute kidney injury (AKI) by activating E3 ubiquitin ligase, the HMG-CoA reductase degradation protein 1 (HRD1), induced ubiquitination and degradation of GSK3β and CK1α, two β-catenin complex members [7]. Here, S100A16 is linked to acute kidney injury.