The most relevant findings are as follows: (i) CRT was associated with survival to discharge with successful weaning of the vast majority of patients from inotropic support; (ii) intra‐procedural mortality was extremely low; (iii) CRT prolonged survival, improved NYHA class status, reduced hospital readmissions for HF, and reduced BNP levels; and (iv) a higher prevalence of males and individuals with a history of LBBB and more pronounced left ventricular dilation, as assessed by measurement of end‐diastolic volume, was observed in the CRT responder group. This evidence concerns the gene NPPB and hydrops fetalis.