Moreover, studies have shown that in rats with heart failure, the exacerbation of myocardial fibrosis was accompanied by the upregulation of the fibrosis‐promoting gene Fgfr2 and the downregulation of Adcy1; while following intervention with Qishen granules, myocardial fibrosis was attenuated with the downregulation of Fgfr2 and the upregulation of Adcy1 [37]. The gene discussed is ADCY1; the disease is heart failure.