Despite recent evidence for a genetically determined IL-6 association with brain structure (Williams et al., 2022), it seems that inflammation in psychosis has heterogeneous mechanisms at play that lead to pleiotropic expressions with distinct neuroanatomical signatures (e.g. Interferon-gamma [IFN-γ] associated with increased grey matter volume and IL-6 associated with reduced grey matter volume (Lalousis et al., 2023). The gene discussed is IFNG; the disease is psychotic disorder.