Others have reported that PRMT5 is overexpressed in HNSCC (71), and inhibition of PRMT5 by EPZ015666 (GSK3235025) reduces H3K4me3-mediated Twist1 transcription and suppresses the carcinogenesis and metastasis of HNSCC (72). The gene discussed is TWIST1; the disease is head and neck squamous cell carcinoma.