The expression of both PRMT5 and PRMT1 has been tested in multiple head and neck squamous cell carcinoma (HNSCC) and A549 cells where OHKC (immortalized normal oral keratinocytes) and DOK (dysplastic oral keratinocytes) cells serve as normal and dysplastic cell lines (Supplementary Figure S1A). Here, PRMT5 is linked to head and neck squamous cell carcinoma.