LEP and myocardial infarction: The MBDA-based CVD risk score combines the MBDA score with three of its biomarkers (leptin, MMP-3 and TNR-R1), age, and four traditional clinical CVD risk factors (diabetes, hypertension, tobacco use and history of a high-risk cardiovascular condition) to predict the 3-year risk for myocardial infarction (MI), stroke or CVD death in patients with RA [6].