Among the growing list of pro-inflammatory chemokines involved in stroke, CCL2 (also known as MCP1) and its receptor CCR2 are particularly noteworthy because emerging clinical evidence suggests a positive correlation between the severity of stroke progression and CCL2 levels from patients’ serum and/or cerebrospinal fluid.15 However, the role of CCL2 in BBB damage after stroke remains obscure, and the exact regulatory mechanism of CCL2 production is not defined. This evidence concerns the gene CCL2 and Stroke.