CCR2 and stroke disorder: Among the growing list of pro-inflammatory chemokines involved in stroke, CCL2 (also known as MCP1) and its receptor CCR2 are particularly noteworthy because emerging clinical evidence suggests a positive correlation between the severity of stroke progression and CCL2 levels from patients’ serum and/or cerebrospinal fluid.15 However, the role of CCL2 in BBB damage after stroke remains obscure, and the exact regulatory mechanism of CCL2 production is not defined.