Using this viral approach, we replicated key stroke-related phenotypes observed in the Slc4a4-icKO mouse line after the stroke, including enlarged infarct size (Figures S4D and S4E), impaired reactive astrocytes response (Figures S4D, S4F, and S4G), increased transcellular and paracellular transport at the BBB (Figures S4D, S4H, and S4I), and increased capillary size (Figures S4D and S4J). Here, SLC4A4 is linked to stroke disorder.