The acromegaly group had higher levels of fasting glucose (p = 0.001), insulin (p = 0.003), HOMA-IR (p < 0.001), HbA1c (p < 0.001) and ALP ( p = 0.002) than the control group, while the two groups had similar AST (p = 0.637), ALT (p = 0.575), GGT (p = 0.369), Tchol (p = 0.470), LDL cholesterol (p = 0.529), HDL cholesterol (p = 0.476) and TG (p = 0.633). The gene discussed is INS; the disease is acromegaly.