We review the past, current, and future state of therapeutic strategies for tumors associated with NF-1.<h4>Recent findings</h4>Therapeutic efforts for NF-1-associated tumors have centered around inhibiting Ras output, leading to the clinical success of downstream MEK inhibition for plexiform neurofibromas and low-grade gliomas. The gene discussed is MAP2K7; the disease is plexiform neurofibroma.