This did not remain significant after correction for multiple testing but the pattern for both these genes was also seen in the METABRIC dataset, strikingly so for GATA3. The trend for greater proportion of GATA3-mutated tumours in the controls than in the cases with time to recurrence is evident in the METABRIC dataset (Fig. 2B) in contrast to TP53 which showed highly significant differences in early recurrences (p < 0.00001) but not in later recurrences (> 10 yr p = 0.1 and > 20 yr p = 0.82) (Fig. 2C). This evidence concerns the gene TP53 and neoplasm.