NPPB and chronic kidney disease: In line with this, NT-pro BNP levels were higher in patients with CKD during index hospitalization (median 1957 vs. 1441; p = 0.001), as well as at 6 months (median 1993 vs. 1226; p = 0.001), 12 months (median 1499 vs. 1126 p = 0.022) and 30 months (median 2337 vs. 452; p = 0.001) thereafter (Fig. 2; right panel).