HLA-DRB1 and colorectal carcinoma: Previously, our group and others determined macrophage and T-cell recruitment may differ significantly in CRC according to the prevalence of fusobacteria.6,7,17 HLA-DRA, HLA-DRB, and Alpha-2-macroglobulin (A2M) were all found to be up-regulated in fusobacteria high immune segments in our analysis.