encapsulated biocompatible PLGA‐coated TMZ and IL‐15 NPs with cRG encapsulated biocompatible PLGA‐coated TMZ and IL‐15 NPs with cRGD‐decorated NK cell membranes (R‐NKm@NPs) and designed a system of NPs that induces immunostimulatory TME and was used for chemoimmunotherapy of GBM. The gene discussed is IL15; the disease is glioblastoma.