We also found that doxorubicin‐polyglycerol‐nanodiamond conjugate (nanoDOX) inhibits STAT3 activity of GBCs via GBM‐associated macrophage delivery and reduces IL‐6 export from GBCs to astrocytes, thus reducing astrocyte‐induced GBC We also found that feedback activation can be eliminated. This evidence concerns the gene STAT3 and glioblastoma.