In contrast, Med1 negatively modulates the expression of metastasis-related genes and is downregulated in melanoma7 and lung cancer.8 Med1 expression considerably decreases during bladder cancer progression from benign urothelium to advanced bladder cancer.9 Although Med1 protein expression is related to the development and metastasis of various cancers, the mechanism of regulation of Med1 protein expression is poorly understood. This evidence concerns the gene MED1 and urinary bladder cancer.