Interestingly, higher levels of circulating endostatin are associated with a disturbed circadian BP pattern in patients with type 2 diabetes, with significantly higher circulating endostatin levels in ‘non-dippers’ (i.e. patients with reduced decline in nocturnal BP) compared with ‘dippers’ (i.e. normal dipping pattern characterized by a >10% dip in the BP during the night).42 According to Wuopio et al.,42 these findings suggest that higher levels of circulating endostatin seen among ‘non-dippers’ may reflect extracellular remodelling due to damage in the kidneys, heart, and vascular tree. Here, COL18A1 is linked to type 2 diabetes mellitus.