Using multivariate logistic regression analysis, after adjusting for clinically relevant confounders [including age, sex, body mass index (BMI), supine BP, antihypertensive medications, prevalent cardiovascular disease, cardiovascular risk factors, and cancer], endostatin remained independently associated with OH (adjusted OR per 10% increase of endostatin in the whole study population = 1.26, 95% CI 1.14–1.40, P < 0.001; Table 2). This evidence concerns the gene COL18A1 and cardiovascular disorder.