NLRP3 and gout: NLRP3 inflammasome is involved in the pathogenesis of HUA and gout as a sensor of metabolic stress, and targeted inhibition of NLRP3 inflammasome may be a key strategy for the prevention and treatment of HUA and gout (Pellegrini et al., 2019; El-Sayed et al., 2022; Zhan et al., 2022).