MAPT and Classical progressive supranuclear palsy: Progressive supranuclear palsy (PSP), a rare neurodegenerative disorder of unknown origin, is pathologically characterized by abnormal tau deposition in the form of globose neuro-fibrillary tangles, tufted astrocytes, coiled bodies, and threads, with a predominance of 4-repeat (4R) tau isoforms (1, 2).