Interestingly, Wang et al. recently reported that tumor-derived EVPs containing fatty acids, particularly palmitic acid, are taken up by Kupffer cells in metastasis-free livers of tumor-bearing mice and cancer patients, inducing tumor necrosis factor α (TNFα) secretion and dysregulating liver metabolism by altering the expression of cytochrome c-encoding genes[126]. Here, CYCS is linked to neoplasm.