These unshielded non-coding RNAs enriched in EVPs from tumor-activated stromal cells acted as damage-associated molecular patterns (DAMPs) signals, triggering a feedback loop that activated the pattern recognition receptor retinoic acid-inducible gene I (RIG-I) and interferon-stimulated genes in breast cancer and innate immune cells[64]. The gene discussed is RIGI; the disease is breast carcinoma.