ERG and Familial prostate cancer: Their ExoDx Prostate (IntelliScore) is a urine test that utilizes exosomal RNA to detect three biomarkers [ERG (V-ets erythroblastosis virus E26 oncogene homologs), PCA3 (prostate cancer antigen 3), and SPDEF (SAM pointed domain-containing ETS transcription factor)] for the assessment of prostate cancer risk[142].