(1) The first occurrence of hypothyroidism: At the 25th week after anti-PD1 administration, a significant increase in thyroid autoimmune antibodies (ARCHITECT Anti-Tg/Anti-TPO Reagent Kit, Chemiluminescent Micro-Particle Immunoassay) combined with hypothyroidism was found, while adrenal function remained normal during the same period, and growth hormone (GH) and sex hormone were not tested. The gene discussed is TPO; the disease is hypothyroidism.