TG and hypothyroidism: (1) The first occurrence of hypothyroidism: At the 25th week after anti-PD1 administration, a significant increase in thyroid autoimmune antibodies (ARCHITECT Anti-Tg/Anti-TPO Reagent Kit, Chemiluminescent Micro-Particle Immunoassay) combined with hypothyroidism was found, while adrenal function remained normal during the same period, and growth hormone (GH) and sex hormone were not tested.