MB and Renal insufficiency: Not surprisingly, ischemic necrosis of muscles, caused by limb branch artery dissection or decreased aortic perfusion blood flow, can promote the release of creatine kinase (CK), myoglobin, free calcium, etc. Myoglobin is the principal compound corresponding to renal failure, which induces renal tubular obstruction, tubular necrosis, and lipid peroxidation, especially in the presence of insufficient blood volume and acidic urine (21–25).